Optimization of Supercritical Extraction of Linalyl Acetate from Lavender via Box-Behnken Design

• Published in: Chemical engineering & technology Vol. 35; no. 9; pp. 1641 - 1648
• Main Authors: Ghoreishi, S. M., Kamali, H., Ghaziaskar, H. S., Dadkhah, A. A.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.09.2012; WILEY‐VCH Verlag; Wiley-VCH
• Subjects: Applied sciences; Box-Behnken design; Chemical engineering; Exact sciences and technology; Lavender; Linalool; Linalyl acetate; Liquid-liquid extraction; Supercritical carbon dioxide; Supercritical fluid extraction; Design; Energy consumption; Carbon dioxide; Flame ionization detector; Extract; Essential oil; Supercritical state; Supercritical fluid extraction; Semicontinuous; Optimization
• ISSN: 0930-7516; 1521-4125
• DOI: 10.1002/ceat.201100429

Essential oil was extracted from lavender using supercritical carbon dioxide by means of a newly developed periodic static‐dynamic (PSD) procedure and the conventional semicontinuous (SC) technique. Applying GC‐FID analysis in conjunction with Box‐Behnken design, an optimum overall extraction yield (94.4 %) was obtained via PSD in contrast to 90 % for the SC method. The results indicate that supercritical fluid extraction is a viable technique for separation of constituents such as linalyl acetate, linalool, fenchone, and camphor for pharmaceutical and medicinal applications. Furthermore, a substantial reduction of energy consumption and solvent consumption is achieved with the developed PSD process compared to the conventional SC method. Essential oil from Isfahan lavender flowers was extracted applying supercritical carbon dioxide in a newly developed periodic static‐dynamic procedure and a conventional semicontinuous method for production of camphor, fenchone, linalyl acetate, and linalool. In order to achieve maximum extraction yields, the operating conditions of both methods were optimized by means of response surface design.