Recent Advances in Transition‐Metal‐Catalyzed Oxidative Annulations to Benzazepines and Benzodiazepines

Benzazepines and benzodiazepines, benzofused seven‐membered N‐heterocycles, compose an important family of natural products and pharmaceuticals. Although certainly important and effectives, classical synthetic methods of these cyclic compounds involve methodologies that often require multistep proce...

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 362; no. 22; pp. 4861 - 4875
Main Authors Velasco‐Rubio, Álvaro, Varela, Jesús A., Saá, Carlos
Format Journal Article
LanguageEnglish
Published Heidelberg Wiley Subscription Services, Inc 18.11.2020
Subjects
Benzazepine
Benzodiazepine
Benzodiazepines
Cyclic compounds
C−H activation
Hydrogen bonds
Natural products
Oxidative annulation
Sustainability
Transition metals
Transition-metal catalyst
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Summary:Benzazepines and benzodiazepines, benzofused seven‐membered N‐heterocycles, compose an important family of natural products and pharmaceuticals. Although certainly important and effectives, classical synthetic methods of these cyclic compounds involve methodologies that often require multistep procedures, with generation of waste materials and lack of sustainability. By contrast, cycloadditions based on transition metal catalyzed C−H bond activations (oxidative annulations) have emerged as appealing strategies for more sustainable synthetic processes. In this review, we focus our attention to describe the state‐of‐the‐art transition‐metal‐catalyzed annulations via C−H activations to benzazepines and benzodiazepines.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202000808