Effects of conditions for preparing nanoparticles composed of aminoethylcarbamoyl-β-cyclodextrin and ethylene glycol diglycidyl ether on trap efficiency of a guest molecule
Nanoparticles comprising copolymers of aminoethylcarbamoyl-β-cyclodextrin (AEC-β-CD) and ethylene glycol diglycidyl ether (EGDGE) are prepared by an interfacial polyaddition reaction in a miniemulsion system. Polymers are formed in a W/O emulsion containing 0.25–10.0% (w/w) water and 5.0% (w/w) surf...
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Published in | International journal of pharmaceutics Vol. 311; no. 1; pp. 215 - 222 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Amsterdam
Elsevier B.V
27.03.2006
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Nanoparticles comprising copolymers of aminoethylcarbamoyl-β-cyclodextrin (AEC-β-CD) and ethylene glycol diglycidyl ether (EGDGE) are prepared by an interfacial polyaddition reaction in a miniemulsion system. Polymers are formed in a W/O emulsion containing 0.25–10.0% (w/w) water and 5.0% (w/w) surfactant (MO-3S, tetraglycerin monoester, HLB 8.8), where simple particles are predominantly obtained when the water content is 1.0% and 5.0%. Notably, nano-size small particles (diameter: 0.3
μm) are formed under the condition of 5.0% water and 5.0% surfactant, which have the highest β-CD contents (75.5
wt.%) and the most positive ζ-potential (53.6
mV). The ζ-potential measurement indicates that the obtained particles have positive charge due to protonation of their amino groups below around pH 10. Actually, uptake of 8-anilino-1-naphthalenesulfonic acid (ANS) bearing negative charge (SO
3
−) and moderate hydrophobicity depends on the magnitude of ζ-potential of the particles; viz., the particles with ζ-potential of 53.6
mV show the highest efficiency of uptake. The diameter and the β-CD contents are closely related with the water/surfactant ratio, and the ζ-potentials are dependent on both the diameter and the β-CD contents. Inclusion of ANS into the CD cavity of EGDGE/AEC-β-CD particles can be controlled by electrostatic interaction between ANS (negatively charged) and the particle (positively charged). Namely, synergistic effect of cavity-inclusion and electrostatic interaction can dominate the uptake of guest molecules by the particles. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0378-5173 1873-3476 |
DOI: | 10.1016/j.ijpharm.2005.12.015 |