Three-dimensional quantitative imaging of retinal and choroidal blood flow velocity using joint Spectral and Time domain Optical Coherence Tomography

Recently, joint Spectral and Time domain Optical Coherence Tomography (joint STdOCT) has been proposed to measure ocular blood flow velocity. Limitations of CCD technology allowed only for two-dimensional imaging at that time. In this paper we demonstrate fast three-dimensional STdOCT based on ultra...

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Bibliographic Details
Published inOptics express Vol. 17; no. 13; pp. 10584 - 10598
Main Authors Szkulmowska, Anna, Szkulmowski, Maciej, Szlag, Daniel, Kowalczyk, Andrzej, Wojtkowski, Maciej
Format Journal Article
LanguageEnglish
Published United States 22.06.2009
Subjects
Angiography - methods
Automation
Choroid - blood supply
Equipment Design
Fourier Analysis
Humans
Imaging, Three-Dimensional
Lasers
Models, Theoretical
Optics and Photonics
Retinal Vessels - pathology
Tomography, Optical Coherence - instrumentation
Tomography, Optical Coherence - methods
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Summary:Recently, joint Spectral and Time domain Optical Coherence Tomography (joint STdOCT) has been proposed to measure ocular blood flow velocity. Limitations of CCD technology allowed only for two-dimensional imaging at that time. In this paper we demonstrate fast three-dimensional STdOCT based on ultrahigh speed CMOS camera. Proposed method is straightforward, fully automatic and does not require any advanced image processing techniques. Three-dimensional distributions of axial velocity components of the blood in human eye vasculature are presented: in retinal and, for the first time, in choroidal layer. Different factors that affect quality of velocity images are discussed. Additionally, the quantitative measurement allows to observe a new interesting optical phenomenon - random Doppler shift in OCT signals that forms a vascular pattern at the depth of sclera.
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ISSN:1094-4087
1094-4087
DOI:10.1364/oe.17.010584