Dynamic swelling behavior of γ-radiation induced polyelectrolyte poly(AAm- co-CA) hydrogels in urea solutions

• Published in: International journal of pharmaceutics Vol. 301; no. 1; pp. 102 - 111
• Main Authors: Karadağ, Erdener, Üzüm, Ömer Barış, Saraydin, Dursun, Güven, Olgun
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 14.09.2005; Elsevier
• Subjects: Acrylamide/crotonic acid; Acrylamides - chemistry; Acrylamides - radiation effects; Adsorption; Biological and medical sciences; Cross-Linking Reagents; Crotonates - chemistry; Crotonates - radiation effects; Diffusion; Gamma Rays; General pharmacology; Hydrogel; Hydrogels - chemistry; Hydrogels - radiation effects; Kinetics; Medical sciences; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Solutions; Swelling; Urea; Urea - chemistry; γ-Radiation; Urea; Hydrogel; Swelling; Diffusion; γ-Radiation; Acrylamide/crotonic acid; Pharmaceutical technology; Colloidal gel; Polyelectrolyte; Acrylamide; Acids; Dosage form; Behavior; Swelling: Diffusion; Solution
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2005.05.026

The aim of this study was to investigate the equilibrium swelling properties in urea solutions of γ-radiation induced polyelectrolyte copolymeric hydrogels consisting of acrylamide (AAm) and crotonic acid (CA). Poly(acrylamide- co-crotonic acid), poly(AAm- co-CA) hydrogels containing different amounts of CA were obtained in the form of rods after radiation. Swelling experiments were performed in aqueous urea solutions at 25 °C, gravimetrically. The hydrogels showed large extents of swelling in aqueous (urea/water) media the swelling being highly dependent on the chemical composition of the hydrogels and irradiation dose. The percentage swelling of poly(AAm- co-CA) hydrogels was between 1160 and 4250%, while that of the AAm hydrogels was between 670 and 900%. The diffusional exponent values ( n) are between 0.51 and 0.66, hence the diffusion of urea/water into the hydrogels is non-Fickian. Equilibrium urea/water contents of the hydrogel systems were changed between 0.870 and 0.977.