Association of the herpes simplex virus major tegument structural protein VP22 with chromatin

The abundant tegument protein VP22 has homologs throughout the alphaherpesvirus family. Numerous groups have been involved in the examination of these homologs, trying to decipher their multiple functions. Investigations early on indicated that VP22 associates with chromatin and further evidence has...

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Bibliographic Details
Published inBiochimica et biophysica acta Vol. 1799; no. 3; pp. 200 - 206
Main Authors Ingvarsdottir, Kristin, Blaho, John A.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.03.2010
Subjects
Alphaherpesvirus
Amino Acid Sequence
Animals
Chromatin
Chromatin - metabolism
Gene Expression Regulation, Viral
Herpes simplex virus
Humans
Molecular Sequence Data
Sequence Homology, Amino Acid
U L49
Viral Structural Proteins - metabolism
VP22
VP22
Chromatin
U L49
Herpes simplex virus
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Summary:The abundant tegument protein VP22 has homologs throughout the alphaherpesvirus family. Numerous groups have been involved in the examination of these homologs, trying to decipher their multiple functions. Investigations early on indicated that VP22 associates with chromatin and further evidence has accumulated in recent years, correlating this protein with chromatin and its components. Ongoing and future studies will determine whether this association with chromatin is specific and whether it serves a function during infection in a physiologically relevant setting.
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ISSN:1874-9399
0006-3002
1876-4320
DOI:10.1016/j.bbagrm.2009.08.002