Does the TT Variant of the rs966423 Polymorphism in DIRC3 Affect the Stage and Clinical Course of Papillary Thyroid Cancer?

• Published in: Cancers Vol. 12; no. 2; p. 423
• Main Authors: Hińcza, Kinga, Kowalik, Artur, Pałyga, Iwona, Walczyk, Agnieszka, Gąsior-Perczak, Danuta, Mikina, Estera, Trybek, Tomasz, Szymonek, Monika, Gadawska-Juszczyk, Klaudia, Zajkowska, Klaudia, Suligowska, Agnieszka, Kuchareczko, Artur, Krawczyk, Karol, Kopczyński, Janusz, Chrapek, Magdalena, Góźdź, Stanisław, Kowalska, Aldona
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 12.02.2020
• Subjects: risk factors; overdiagnosis; papillary thyroid cancer; overtreatment
• ISSN: 2072-6694; 2072-6694
• DOI: 10.3390/cancers12020423

Thyroid cancer (TC) is the most common cancer of the endocrine system. Most new diagnoses are of low-grade papillary thyroid cancer (PTC), suggesting that PTC may be over-diagnosed. However, the incidence of advanced-stage PTC has increased in recent years. It is therefore very important to identify prognostic factors for advanced PTC. Somatic mutation of the gene at V600E, or the coexistence of the V600E mutation and mutations in the promoter are associated with more aggressive disease. It would also be valuable to identify genetic risk factors affecting PTC prognosis. We therefore evaluated the impact of the rs966423 polymorphism in the gene, including its relationship with unfavorable histopathological and clinical features and mortality, in differentiated thyroid cancer (DTC). The study included 1466 patients diagnosed with DTC from one center. There was no significant association between the genotype at rs966423 (CC, CT, or TT) and any histopathological or clinic factor examined, including initial response to therapy, response at follow-up, or overall mortality, in DTC patients.