Mechanoimmunology: molecular-scale forces govern immune cell functions
Immune cell recognition of antigens is a pivotal process in initiating immune responses against injury, pathogens, and cancers. Breakthroughs over the past decade support a major role for mechanical forces in immune responses, laying the foundation for the emerging field of mechanoimmunology. In thi...
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Published in | Molecular biology of the cell Vol. 29; no. 16; pp. 1919 - 1926 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
The American Society for Cell Biology
08.08.2018
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Abstract | Immune cell recognition of antigens is a pivotal process in initiating immune responses against injury, pathogens, and cancers. Breakthroughs over the past decade support a major role for mechanical forces in immune responses, laying the foundation for the emerging field of mechanoimmunology. In this Perspective, we discuss the mechanical forces acting at the level of ligand-receptor interactions and how they underpin receptor triggering, signal initiation, and immune cell activation. We also highlight the novel biophysical tools and advanced imaging techniques that have afforded us the recent progress in our understanding of the role of forces in immune cell functions. |
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AbstractList | Immune cell recognition of antigens is a pivotal process in initiating immune responses against injury, pathogens, and cancers. Breakthroughs over the past decade support a major role for mechanical forces in immune responses, laying the foundation for the emerging field of mechanoimmunology. In this Perspective, we discuss the mechanical forces acting at the level of ligand-receptor interactions and how they underpin receptor triggering, signal initiation, and immune cell activation. We also highlight the novel biophysical tools and advanced imaging techniques that have afforded us the recent progress in our understanding of the role of forces in immune cell functions. Immune cell recognition of antigens is a pivotal process in initiating immune responses against injury, pathogens, and cancers. Breakthroughs over the past decade support a major role for mechanical forces in immune responses, laying the foundation for the emerging field of mechanoimmunology. In this Perspective , we discuss the mechanical forces acting at the level of ligand–receptor interactions and how they underpin receptor triggering, signal initiation, and immune cell activation. We also highlight the novel biophysical tools and advanced imaging techniques that have afforded us the recent progress in our understanding of the role of forces in immune cell functions. |
Author | Govendir, Matt A Pageon, Sophie V Kempe, Daryan Biro, Maté |
Author_xml | – sequence: 1 givenname: Sophie V surname: Pageon fullname: Pageon, Sophie V organization: EMBL Australia, Single Molecule Science Node, School of Medical Sciences, and – sequence: 2 givenname: Matt A surname: Govendir fullname: Govendir, Matt A organization: EMBL Australia, Single Molecule Science Node, School of Medical Sciences, and – sequence: 3 givenname: Daryan surname: Kempe fullname: Kempe, Daryan organization: EMBL Australia, Single Molecule Science Node, School of Medical Sciences, and – sequence: 4 givenname: Maté surname: Biro fullname: Biro, Maté organization: ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales, Sydney, NSW 2052, Australia |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30088799$$D View this record in MEDLINE/PubMed |
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