Mechanoimmunology: molecular-scale forces govern immune cell functions

Immune cell recognition of antigens is a pivotal process in initiating immune responses against injury, pathogens, and cancers. Breakthroughs over the past decade support a major role for mechanical forces in immune responses, laying the foundation for the emerging field of mechanoimmunology. In thi...

Full description

Saved in:
Bibliographic Details
Published inMolecular biology of the cell Vol. 29; no. 16; pp. 1919 - 1926
Main Authors Pageon, Sophie V, Govendir, Matt A, Kempe, Daryan, Biro, Maté
Format Journal Article
LanguageEnglish
Published United States The American Society for Cell Biology 08.08.2018
Online AccessGet full text

Cover

More Information
Summary:Immune cell recognition of antigens is a pivotal process in initiating immune responses against injury, pathogens, and cancers. Breakthroughs over the past decade support a major role for mechanical forces in immune responses, laying the foundation for the emerging field of mechanoimmunology. In this Perspective, we discuss the mechanical forces acting at the level of ligand-receptor interactions and how they underpin receptor triggering, signal initiation, and immune cell activation. We also highlight the novel biophysical tools and advanced imaging techniques that have afforded us the recent progress in our understanding of the role of forces in immune cell functions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
These authors contributed equally to this work.
ISSN:1059-1524
1939-4586
DOI:10.1091/mbc.E18-02-0120