Sunitinib in Metastatic Renal Cell Carcinoma: A Systematic Review of UK Real World Data
Real world data (RWD) are increasingly used to inform drug reimbursement decisions, but it is unclear how well outcomes from real world studies compare to those of clinical trials. This systematic review seeks to compare outcomes for sunitinib in routine UK clinical practice with the sunitinib regis...
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Published in | Frontiers in oncology Vol. 5; p. 195 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
25.08.2015
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Subjects | |
Online Access | Get full text |
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Summary: | Real world data (RWD) are increasingly used to inform drug reimbursement decisions, but it is unclear how well outcomes from real world studies compare to those of clinical trials. This systematic review seeks to compare outcomes for sunitinib in routine UK clinical practice with the sunitinib registrational and expanded-access program clinical trials.
Systematic review of the real world published literature was undertaken. UK observational studies recording first- or second-line sunitinib efficacy were included. A qualitative summary of the results and comparison to the controlled clinical trials was conducted. Fifteen real world studies were included, 14 of which were only available as posters/presentations.
Real world study reporting quality was generally low, making comparisons with the clinical trials difficult. Practice relating to starting dose, dose modification, timing of therapy initiation, and other factors varied between centers. Median progression-free survival and adverse events were generally comparable to the clinical trial outcomes, but overall survival was not.
There are few published data on sunitinib use in UK clinical practice. Studies are characterized by lack of peer reviewed publication and heterogeneity in design, reporting, and analysis. For use of RWD in the reimbursement setting, data collection and reporting will need to improve.
There are few published data on sunitinib use in UK clinical practice. Studies are characterized by lack of peer reviewed publication and heterogeneity in design, reporting, and analysis. Practice varies considerably between different UK centers. Median progression-free survival and adverse events are generally comparable to the clinical trial outcomes, but overall survival is not. For use of real world data in the reimbursement setting, data collection and reporting will need to improve. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Specialty section: This article was submitted to Genitourinary Oncology, a section of the journal Frontiers in Oncology Edited by: Fabio Grizzi, Humanitas Clinical and Research Center, Italy Miriam Argyropulo-Palmer was an industrial trainee at Pfizer Ltd between August 2013 and July 2014 when the study was performed. Reviewed by: Nicholas Glenn Cost, Cincinnati Children’s Hospital Medical Center, USA; Christoph Seidel, Universitätsklinikum Hamburg-Eppendorf, Germany |
ISSN: | 2234-943X 2234-943X |
DOI: | 10.3389/fonc.2015.00195 |