Antiphospholipid Syndrome following Toxoplasma Retinochoroiditis

• Published in: Ocular immunology and inflammation Vol. 19; no. 5; pp. 311 - 313
• Main Authors: Tavakoli, Mehdi, Roghaee, Shiva, Soheilian, Roham, Soheilian, Masoud
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.10.2011
• Subjects: Accidents; Antibodies, Anticardiolipin - blood; antiphospholipid syndrome; Antiphospholipid Syndrome - etiology; Antiphospholipid Syndrome - immunology; Antiprotozoal Agents - therapeutic use; beta 2-Microglobulin - blood; cardiolipin; Case reports; Chorioretinitis - complications; Chorioretinitis - drug therapy; Chorioretinitis - immunology; Etiology; Female; Hemorrhage; Humans; Immunoglobulin G; Immunoglobulin G - blood; Occlusion; Retina; Retinal Vein Occlusion - immunology; Retinal Vein Occlusion - parasitology; Retinitis; retinochoroiditis; Toxoplasma; Toxoplasmosis; Toxoplasmosis, Ocular - complications; Toxoplasmosis, Ocular - drug therapy; Toxoplasmosis, Ocular - immunology; Veins; Young Adult
• ISSN: 0927-3948; 1744-5078
• DOI: 10.3109/09273948.2011.596302

Purpose: To report a case of antiphospholipid syndrome (APS) following toxoplasma retinochoroiditis. Design: Interventional case report. Method: The patient was a 24-year-old female with an attack of visual loss due to toxoplasma retinochoroiditis concomitant with branch retinal vein occlusion. Retinitis resolved with anti-toxoplasma treatment. However, a recurrent episode of BRVO and vitreous hemorrhage occurred later. Result: In systemic evaluation, evidence of APS was detected, including high titers of anti-cardiolipin antibody, increased beta-2 microglobulin and anti-toxoplasma IgG antibody, and also low titers of C3, C4, and CH50. Conclusion: Ocular toxoplasmosis should be included in the list of etiologies of secondary APS. Systemic evaluation for detection of APS is a necessary approach to patients with toxoplasma retinochoroiditis and concomitant vascular accident.