The differences of platelet response to snake venoms: A comparative study of children and adults

Platelets play a vital role in the coagulation, yet the potential for differences in platelet function, between adults and children, remains underexplored. This is despite the age-related variation in haemostatic proteins, that is encompassed by the term Developmental Haemostasis. Hemotoxins found i...

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Published inToxicon (Oxford) Vol. 52; no. 8; pp. 960 - 963
Main Authors Kern, L.P., Ignjatovic, V., Winkel, K.D., Summerhayes, R., Monagle, P.
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Ltd 15.12.2008
Elsevier
Subjects
Adolescent
Adult
Age Factors
Animal poisons toxicology. Antivenoms
Animals
Australian elapids
Biological and medical sciences
Child
Child, Preschool
Elapid Venoms - pharmacology
Elapidae
Humans
Infant
Medical sciences
Paediatric haemostasis
Platelet aggregation
Platelet Aggregation - drug effects
Toxicology
Australia
Oceania
Australian elapids
Paediatric haemostasis
Platelet aggregation
Aggregation
Vertebrata
Platelet
Hemostasis
Venom
Animal origin
Reptilia
Comparative study
Ophidia
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Summary:Platelets play a vital role in the coagulation, yet the potential for differences in platelet function, between adults and children, remains underexplored. This is despite the age-related variation in haemostatic proteins, that is encompassed by the term Developmental Haemostasis. Hemotoxins found in the venoms of Australian snakes mimic human blood coagulation factors. The effects of Australian snake venoms on platelets, as well as the possible differential response in adults and children were subject of this study.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0041-0101
1879-3150
DOI:10.1016/j.toxicon.2008.09.007