Genetic variations of matrix metalloproteinase-1 and -3 promoter regions and their associations with susceptibility to myocardial infarction in Japanese

• Published in: International journal of cardiology Vol. 92; no. 2; pp. 181 - 186
• Main Authors: Nojiri, Takefumi, Morita, Hiroyuki, Imai, Yasushi, Maemura, Koji, Ohno, Minoru, Ogasawara, Ken, Aizawa, Tadanori, Saito, Akira, Hayashi, Doubun, Hirata, Yasunobu, Sugiyama, Takao, Yamazaki, Tsutomu, Nagai, Ryozo
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.12.2003; Elsevier Science
• Subjects: Aged; Asian Continental Ancestry Group; Association; Biological and medical sciences; Cardiology. Vascular system; Case-Control Studies; Chromosomes, Human, Pair 11 - genetics; Coronary heart disease; Female; Genetic Predisposition to Disease; Genetic Variation; Heart; Humans; Japan - epidemiology; Linkage Disequilibrium; Logistic Models; Male; Matrix Metalloproteinase 1 - genetics; Matrix Metalloproteinase 3 - genetics; Matrix metalloproteinase-1; Matrix metalloproteinase-3; Medical sciences; Middle Aged; Myocardial infarction; Myocardial Infarction - ethnology; Myocardial Infarction - genetics; Myocarditis. Cardiomyopathies; Polymorphism; Polymorphism, Genetic; Promoter Regions, Genetic; Japan; Myocardial infarction; Matrix metalloproteinase-1; Association; Matrix metalloproteinase-3; Polymorphism; Stromelysin 1; Enzyme; Pathogenesis; Variations; Metalloendopeptidases; Cardiovascular disease; Myocardial disease; Genetic determinism; Japanese; Promoter; Peptidases; Sensitivity; Heart disease; Predisposition; Hydrolases; Genetics; Region; Interstitial collagenase
• ISSN: 0167-5273; 1874-1754
• DOI: 10.1016/S0167-5273(03)00100-1

Matrix metalloproteinases (MMPs) are involved in plaque rupture, which is the main pathological cause of myocardial infarction (MI). Recently, several genetic studies have demonstrated that MMP-1 1G/2G polymorphism and MMP-3 5A/6A polymorphism modify each transcriptional activity in allele specific manners. Within this context, we conducted case–control studies to examine whether these genetic polymorphisms are associated with susceptibility to MI. Two groups comprising patients with MI (group-1 164 patients, group-2 302 patients) were compared with control group comprising 335 patients without cardiovascular diseases. The MMP-3 5A allele was more frequent in patients with MI than in the control subjects ( P=0.018 MI group-1, P=0.0059 MI group-2), whereas there was no disease association for MMP-1 genotypes. Logistic regression analyses revealed that MMP-3 5A/6A polymorphism was associated with susceptibility to MI [odds ratio(OR) (95% confidential interval) 1.67 (1.02–2.74); P=0.042, MI group-1; 1.61 (1.12–2.23); P=0.0095, MI group-2]. Other important findings were that there was strong linkage disequilibrium between these polymorphisms, which are located closely on chromosome 11q.22, and that the 5A–1G haplotype was a genetic risk factor for MI (OR 1.97 P=0.0082, MI group-1 OR 1.51 P=0.017, MI group-2). Taken together, the present findings suggest that genetic variations in these MMP genes and especially their haplotype may be useful genetic markers for determining susceptibility to MI in Japanese.