Mitochondrial dysfunction in neurodegenerative diseases

Neurodegenerative diseases are a large group of disabling disorders of the nervous system, characterized by the relative selective death of neuronal subtypes. In most cases, there is overwhelming evidence of impaired mitochondrial function as a causative factor in these diseases. More recently, evid...

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Published inThe Journal of pharmacology and experimental therapeutics Vol. 342; no. 3; pp. 619 - 630
Main Authors Johri, Ashu, Beal, M Flint
Format Journal Article
LanguageEnglish
Published United States The American Society for Pharmacology and Experimental Therapeutics 01.09.2012
Subjects
Animals
Humans
JPET Miniseries: Mitochondria
Mitochondria - pathology
Mitochondrial Dynamics - physiology
Neurodegenerative Diseases - pathology
Neurodegenerative Diseases - physiopathology
Neurons - pathology
Neurons - physiology
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Summary:Neurodegenerative diseases are a large group of disabling disorders of the nervous system, characterized by the relative selective death of neuronal subtypes. In most cases, there is overwhelming evidence of impaired mitochondrial function as a causative factor in these diseases. More recently, evidence has emerged for impaired mitochondrial dynamics (shape, size, fission-fusion, distribution, movement etc.) in neurodegenerative diseases such as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and Alzheimer's disease. Here, we provide a concise overview of the major findings in recent years highlighting the importance of healthy mitochondria for a healthy neuron.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0022-3565
1521-0103
DOI:10.1124/jpet.112.192138