Effect of an ionic compared to a non-ionic X-ray contrast agent on platelets and coagulation during diagnostic cardiac catheterisation

• Published in: Pathophysiology of haemostasis and thrombosis Vol. 32; no. 3; p. 121
• Main Authors: Jung, F, Spitzer, S G, Pindur, G
• Format: Journal Article
• Language: English
• Published: Switzerland 01.05.2002
• Subjects: Aged; Antithrombin III; Blood Platelets - drug effects; Blood Platelets - secretion; Cardiac Catheterization - adverse effects; Contrast Media - chemistry; Contrast Media - pharmacology; Coronary Angiography; Coronary Disease - blood; Coronary Disease - diagnostic imaging; Endothelium, Vascular - injuries; Female; Fibrin Fibrinogen Degradation Products - analysis; Hemostasis - drug effects; Humans; Iohexol - analogs & derivatives; Iohexol - pharmacology; Ioxaglic Acid - pharmacology; Male; Middle Aged; Peptide Fragments - blood; Peptide Hydrolases - blood; Platelet Activation - drug effects; Platelet Count; Prospective Studies; Prothrombin; Serotonin - secretion
• ISSN: 1424-8832
• DOI: 10.1159/000065213

The aim of the present study was to evaluate the effects of ionic (ioxaglate) and non-ionic (iopromide) contrast media on haemostatic parameters ex vivo. In 40 patients undergoing coronary angiography, platelet function (platelet reactivity and serotonin concentration) and coagulation markers [thrombin-antithrombin III complexes, prothrombin fragments (F1+2) and the D-dimers] were measured. The use of an ionic X-ray contrast agent (XCA) (ioxaglate) in diagnostic cardiac catheterisation angiography is associated with lower thrombin generation and lower activation of the platelet system than when a non-ionic XCA is employed (iopromide). The results thus confirm the results of various in vitro studies and animal investigations.