Incorporation of nanoparticles into transplantable decellularized matrices: Applications and challenges

Decellularization of tissues can significantly improve regenerative medicine and tissue engineering by producing natural, less immunogenic, three-dimensional, acellular matrices with high biological activity for transplantation. Decellularized matrices retain specific critical components of native t...

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Bibliographic Details
Published inInternational journal of artificial organs p. 391398818775522
Main Authors Saleh, Tarek M, Ahmed, Ebtehal A, Yu, Lina, Kwak, Ho-Hyun, Hussein, Kamal H, Park, Kyung-Mee, Kang, Byung-Jae, Choi, Ki-Young, Kang, Kyung-Sun, Woo, Heung-Myong
Format Journal Article
LanguageEnglish
Published United States 01.08.2018
Subjects
tissue engineering
nanoparticles
matrices
scaffold
regenerative medicine
Decellularization
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Summary:Decellularization of tissues can significantly improve regenerative medicine and tissue engineering by producing natural, less immunogenic, three-dimensional, acellular matrices with high biological activity for transplantation. Decellularized matrices retain specific critical components of native tissues such as stem cell niche, various growth factors, and the ability to regenerate in vivo. However, recellularization and functionalization of these matrices remain limited, highlighting the need to improve the characteristics of decellularized matrices. Incorporating nanoparticles into decellularized tissues can overcome these limitations because nanoparticles possess unique properties such as multifunctionality and can modify the surface of decellularized matrices with additional growth factors, which can be loaded onto the nanoparticles. Therefore, in this minireview, we highlight the various approaches used to improve decellularized matrices with incorporation of nanoparticles and the challenges present in these applications.
ISSN:1724-6040
DOI:10.1177/0391398818775522