Carotid distensibility characterized via the isometric exercise pressor response
Laboratory for Cardiovascular Research, Hebrew Rehabilitation Center for Aged, Beth Israel Deaconess Medical Center, and Division on Aging, Harvard Medical School, Boston, Massachusetts 02131 Distensibility of the large elastic arteries is a key index for cardiovascular health. Distensibility, usual...
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Published in | American journal of physiology. Heart and circulatory physiology Vol. 283; no. 6; pp. H2592 - H2598 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.12.2002
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Subjects | |
Online Access | Get full text |
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Summary: | Laboratory for Cardiovascular Research, Hebrew
Rehabilitation Center for Aged, Beth Israel Deaconess Medical
Center, and Division on Aging, Harvard Medical School,
Boston, Massachusetts 02131
Distensibility of the large elastic
arteries is a key index for cardiovascular health. Distensibility,
usually estimated from resting values in humans, is not a static
characteristic but a negative curvilinear function of pressure. We
hypothesized that differences in vascular function with gender and age
may only be recognized if distensibility is quantified over a range of pressures. We used isometric handgrip exercise to induce progressive increases in pressures and carotid diameters, thereby enhancing the
characterization of distensibility. In 30 volunteers, evenly distributed by gender and age across the third to fifth decades of
life, we derived pulsatile distensibility slopes as a function of
arterial pressure for a dynamic distensibility index and compared it
with a traditional static index at a reference pressure of 95 mmHg. We
also assessed intima-media thickness (IMT). We found that women had
greater distensibility slopes within each decade, despite comparable
IMT. Furthermore, declines in distensibility slope with increasing age
were correlated to increased IMT. The static distensibility index
failed to show gender-related differences in distensibility but did
show age-related differences. Our results indicate that gender- and
age-related differences can be manifest even in young, healthy adults
and may only be identified with techniques that assess carotid
distensibility across a range of pressures.
carotid arteries; ultrasonography; compliance; vascular |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0363-6135 1522-1539 |
DOI: | 10.1152/ajpheart.00309.2002 |