Genetic factor(s) influence scar formation in experimental pyelonephritis

Two inbred strains of rat have been identified that show markedly different responses to experimentally induced renal infection. Experiments involving these two strains and their F1 progeny have shown that a genetic factor either protects the host from a tissue-destructive inflammatory response (aut...

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Bibliographic Details
Published inNephron (2015) Vol. 40; no. 3; p. 374
Main Authors Miller, T E, Findon, G
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1985
Subjects
Animals
Chromosome Aberrations - genetics
Chromosome Disorders
Cicatrix - genetics
Escherichia coli Infections - genetics
Female
Genes, Dominant
Genes, Recessive
Male
Pyelonephritis - genetics
Rats
Rats, Inbred Strains
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Summary:Two inbred strains of rat have been identified that show markedly different responses to experimentally induced renal infection. Experiments involving these two strains and their F1 progeny have shown that a genetic factor either protects the host from a tissue-destructive inflammatory response (autosomal dominant gene) or potentiates lesion formation (autosomal recessive gene). The data are the first indication that genetic factors may determine the degree of renal damage in pyelonephritis.
ISSN:1660-8151
DOI:10.1159/000183497