Effect of prenylated flavonoids and chalcones isolated from Artocarpus species on platelet aggregation in human whole blood

• Published in: Journal of natural medicines Vol. 64; no. 3; pp. 365 - 369
• Main Authors: Jantan, Ibrahim, Mohd Yasin, Yusyila H., Jamil, Shajarahtunnur, Sirat, Hasnah, Basar, Norazah
• Format: Journal Article
• Language: English
• Published: Japan Springer Japan 01.07.2010
• Subjects: Artocarpus - chemistry; Biomedical and Life Sciences; Biomedicine; Chalcones - chemistry; Chalcones - isolation & purification; Chalcones - pharmacology; Complementary & Alternative Medicine; Flavonoids - chemistry; Flavonoids - isolation & purification; Flavonoids - pharmacology; Humans; Medicinal Chemistry; Molecular Structure; Pharmacology/Toxicology; Pharmacy; Plant Sciences; Platelet Aggregation - drug effects; Cycloheterophyllin; Antiplatelet aggregation; Arachidonic acid; species; Human whole blood; 2′,4′-dihydroxy-4-methoxy-3′-prenyldihydrochalcone
• ISSN: 1340-3443; 1861-0293
• DOI: 10.1007/s11418-010-0410-0

Five prenylflavonoids and two prenylchalcones from Artocarpus lowii King, A. scortechinii King and A. teysmanii Miq., and acetylated derivatives of cycloheterophyllin and artonin E were investigated for their ability to inhibit arachidonic acid (AA), collagen and adenosine diphosphate (ADP)-induced platelet aggregation in human whole blood by using an electrical impedance method. Among the tested compounds, only cycloheterophyllin inhibited AA-induced platelet aggregation with an IC 50 value of 100.9 μM. It also showed strong inhibition against ADP-induced aggregation, with an IC 50 value of 57.1 μM. Isobavachalcone, 2′,4′-dihydroxy-4-methoxy-3′-prenyldihydrochalcone, cycloartobiloxanthone, artonin E and artonin E triacetate showed selective inhibition against ADP-induced aggregation, with IC 50 values ranging from 55.3 to 192.0 μM, but did not show such effect against other inducers.