Low sodium diet in essential hypertension. Effect on blood cell ions and hemodynamic parameters

• Published in: American journal of hypertension Vol. 5; no. 9; p. 661
• Main Authors: Krzesinski, J M, Du, F, Pecqueux, M L, Rorive, G
• Format: Journal Article
• Language: English
• Published: United States 01.09.1992
• Subjects: Adult; Blood Platelets - chemistry; Calcium - blood; Calcium - metabolism; Diet, Sodium-Restricted; Erythrocytes - chemistry; Erythrocytes - drug effects; Female; Hemodynamics - drug effects; Hemodynamics - physiology; Humans; Hydrogen-Ion Concentration; Hypertension - diet therapy; Male; Middle Aged; Models, Biological; Muscle, Smooth, Vascular - cytology; Muscle, Smooth, Vascular - metabolism; Sodium - blood; Vascular Resistance - drug effects; Vascular Resistance - physiology
• ISSN: 0895-7061
• DOI: 10.1093/ajh/5.9.661

The influence of salt restriction for 3 months on blood pressure, peripheral vascular resistance (observed by occlusive plethysmography), erythrocyte sodium, platelet calcium, and pH, was studied in eight untreated essential hypertensive patients. A low salt diet decreases blood pressure, vascular resistances, erythrocyte sodium, and platelet calcium, but not platelet pH. A strong positive correlation was noted between baseline platelet calcium and vascular resistances (r = 0.95, P less than .01). But during the salt restriction period, a negative correlation has been observed between the changes in these parameters, which casts doubt on the use of the platelet as a model of the smooth muscle cell.