Long-term survival results of patients with locally advanced gastric cancer and pathological complete response after neoadjuvant chemotherapy and resection
To date, the long-term outcomes of patients with locally advanced gastric cancer (LAGC) who achieved a pathological complete response (pCR) after neoadjuvant therapy are elusive. To evaluate the impact of pCR on the long-term survival of LAGC patients who underwent neoadjuvant therapy and evaluate t...
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Published in | Translational cancer research Vol. 9; no. 2; pp. 529 - 535 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
China
AME Publishing Company
01.02.2020
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Subjects | |
Online Access | Get full text |
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Summary: | To date, the long-term outcomes of patients with locally advanced gastric cancer (LAGC) who achieved a pathological complete response (pCR) after neoadjuvant therapy are elusive. To evaluate the impact of pCR on the long-term survival of LAGC patients who underwent neoadjuvant therapy and evaluate the necessity of postoperative adjuvant chemotherapy.
We conducted a retrospective study of clinicopathological and survival data of patients who achieved a pCR after neoadjuvant therapy and resection at the China National Cancer Center between January 2007 and December 2018.
Ultimately, 39 patients enrolled in the current study, with a median follow-up time was 30.4 (range 2.5-101.6) months. The 3- and 5-year overall survival (OS) rates were 88.9% and 88.9%, respectively. And the 3- and 5-year disease-free survival (DFS) rates were 88.9% and 88.9%, respectively. During the follow-up, recurrence was observed in 3 patients. Of all 39 patients, 51.3% (n=20) received postoperative adjuvant chemotherapy and 48.7% (n=19) did not. There was no significant difference in OS (P=0.48) and DFS (P=0.47) between patients who underwent postoperative adjuvant chemotherapy and patients who did not.
Patients with LAGC who achieved a pCR after neoadjuvant therapy and resection might have a favorable OS and DFS. Our study failed to demonstrate the benefit of adjuvant chemotherapy for those patients. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Contributions: (I) Conception and design: T Wang, A Zhou, J Jin, Y Chen, D Zhao; (II) Administrative support: Y Chen, D Zhao; (III) Provision of study materials or patients: T Wang, N Wang; (IV) Collection and assembly of data: T Wang, N Wang, H Zhou; (V) Data analysis and interpretation: T Wang, N Wang; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. |
ISSN: | 2218-676X 2219-6803 |
DOI: | 10.21037/tcr.2019.11.37 |