Resistance of Mycoplasma pneumoniae to erythromycin and other antibiotics

A case is reported of a 14-year-old girl who had M. pneumoniae pneumonia, and in whom the resistance of the organism increased suddently from a minimal inhibitory concentration of erythromycin of 0.008 to 400 γ per milliliter 2 weeks after the beginning of erythromycin therapy. At the same time the...

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Bibliographic Details
Published inThe Journal of pediatrics Vol. 76; no. 3; pp. 438 - 443
Main Authors Niitu, Yasutaka, Hasegawa, Sumio, Suetake, Tomiko, Kubota, Hideo, Komatsu, Shigeo, Horikawa, Masahiro
Format Journal Article
LanguageEnglish
Published United States Mosby, Inc 01.03.1970
Subjects
Adolescent
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Complement Fixation Tests
Drug Resistance, Microbial
Erythromycin - pharmacology
Female
Fermentation
Hemagglutination Tests
Humans
Leucomycins - pharmacology
Lincomycin - pharmacology
Microbial Sensitivity Tests
Mycoplasma - drug effects
Mycoplasma - immunology
Mycoplasma - isolation & purification
Mycoplasma Infections - diagnostic imaging
Mycoplasma Infections - drug therapy
Oleandomycin - pharmacology
Radiography
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Summary:A case is reported of a 14-year-old girl who had M. pneumoniae pneumonia, and in whom the resistance of the organism increased suddently from a minimal inhibitory concentration of erythromycin of 0.008 to 400 γ per milliliter 2 weeks after the beginning of erythromycin therapy. At the same time the organism developed resistance to oleandomycin, spiramycin, leucomycin, josamycin, and lincomycin. The clinical course was uneventful in spite of the emergence of resistance; the radiologic findings returned to normal 3 weeks after the beginning of erythromycin therapy.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0022-3476
1097-6833
DOI:10.1016/S0022-3476(70)80485-1