Prevalence and genotypes of human papilloma virus infection in CIN3 in Beijing, China

To investigate the incidence of single and multiple human papillomavirus (HR-HPV) infection in CIN3 patients before operation. The complete clinical data of patients with CIN3 by biopsy were collected. HPV23 typing in the first 3 months of the treatment was detected. The infection rate of HPV was an...

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Published inTranslational cancer research Vol. 9; no. 3; pp. 1978 - 1984
Main Authors Zhao, Xuan-Yu, Kong, Wei-Min, Jiao, Si-Meng, Song, Dan, Chen, Jiao, Shang, Ruo-Tian
Format Journal Article
LanguageEnglish
Published China AME Publishing Company 01.03.2020
Subjects
Original
genotypes
multiple infection
Papilloma virus
CIN3
conization
human papillomavirus (HPV) infection
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Summary:To investigate the incidence of single and multiple human papillomavirus (HR-HPV) infection in CIN3 patients before operation. The complete clinical data of patients with CIN3 by biopsy were collected. HPV23 typing in the first 3 months of the treatment was detected. The infection rate of HPV was analyzed. One thousand and fifty-one HPV subtypes were detected in 679 patients with HPV (+) CIN3 with primary conization, of which the top ten were HPV16, 33, 31, 58, 6, 52, 18, 43, 51, 11, 68, respectively. Among them, single subtype HPV infection accounted for 64.36%, while multiple HPV infection accounted for 35.64%. For multiplex HPV infection, there were 2, 3, 4 species, and 148 (21.80%), 69 (10.16%), 16 (2.36%), 9 (1.33%) cases of multiple HPV infection of 5 and above HPV subtypes respectively. The incidence of multiple HPV infection in CIN3 patients in 2015 was higher than that in 2012 (39.01% 30.08%, P=0.019), and the proportion of multiple infections in HPV was higher than that in the 2014 group. The top 10 HPV subtypes of the CIN3 patients were included in HPV nine valence vaccines except HPV43 and 51.
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Contributions: (I) Conception and design: XY Zhao, WM Kong; (II) Administrative support: None; (III) Provision of study materials or patients: None; (IV) Collection and assembly of data: SM Jiao, J Chen; (V) Data analysis and interpretation: XY Zhao, D Song; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.
ISSN:2218-676X
2219-6803
DOI:10.21037/tcr.2020.01.59