Comparison of T-2 Toxin and HT-2 Toxin Distributed in the Skeletal System with That in Other Tissues of Rats by Acute Toxicity Test

• Published in: Biomedical and environmental sciences Vol. 30; no. 11; pp. 851 - 854
• Main Authors: YU, Fang Fang, LIN, Xia Lu, YANG, Lei, LIU, Huan, WANG, Xi, FANG, Hua, LAMMI, Mikko J., GUO, Xiong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2017; Institute of Endemic Diseases, School of Public Health of Health Science Center, Xi'an Jiaotong University, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an 710061, Shaanxi, China%Institute of Endemic Diseases, School of Public Health of Health Science Center, Xi'an Jiaotong University, Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, Xi'an 710061, Shaanxi, China; Department of Integrative Medical Biology, University of Ume?, Ume? 90187, Sweden
• Subjects: Animals; Bone and Bones - chemistry; Bone and Bones - metabolism; Rats; Rats, Sprague-Dawley; T-2 Toxin - analogs & derivatives; T-2 Toxin - pharmacokinetics; T-2 Toxin - toxicity; Tissue Distribution; Toxicity Tests, Acute
• ISSN: 0895-3988; 2214-0190; 2214-0190
• DOI: 10.3967/bes2017.115

Twelve healthy rats were divided into the T-2 toxin group receiving gavage of 1 mg/kg T-2 toxin and the control group receiving gavage of normal saline. Total relative concentrations of T-2 toxin and HT-2 toxin in the skeletal system（thighbone, knee joints, and costal cartilage） were significantly higher than those in the heart, liver, and kidneys（P 〈 0.05）. The relative concentrations of T-2 toxin and HT-2 toxin in the skeletal system（thighbone and costal cartilage） were also significantly higher than those in the heart, liver, and kidneys. The rats administered T-2 toxin showed rapid metabolism compared with that in rats administered HT-2 toxin, and the metabolic conversion rates in the different tissues were 68.20%-90.70%.