Identification of nasopharyngeal carcinoma from photoluminescence spectra of 3C-SiC nanocrystals

The identification of intracellular pH (pHi) during carcinogenesis progression plays a crucial role in the studies of biochemistry, cytology, and clinical medicine. In this work, 3C-SiC nanocrystals (NCs), which can effectively monitor the pH environment by using the linear relation between photolum...

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Published inJournal of applied physics Vol. 122; no. 12
Main Authors Wang, Li-Fen, Guo, Jun-Hong, Huang, Zhi-Chun, Gu, Jian-Sen, Feng, Li-Ren, Liu, Li-Zhe
Format Journal Article
LanguageEnglish
Published Melville American Institute of Physics 28.09.2017
Subjects
Applied physics
Biocompatibility
Carcinogens
Clinical medicine
Cytology
Fluorescent indicators
Nanocrystals
Photoluminescence
Toxicity
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Summary:The identification of intracellular pH (pHi) during carcinogenesis progression plays a crucial role in the studies of biochemistry, cytology, and clinical medicine. In this work, 3C-SiC nanocrystals (NCs), which can effectively monitor the pH environment by using the linear relation between photoluminescence intensity and surface OH– and H+ concentration, are adapted as fluorescent probes for monitoring carcinogenesis progression of nasopharyngeal carcinoma. Our results demonstrated that 3C-SiC NCs are compatible with living cells and have low cytotoxicity. The pHi measurements in different carcinogenesis environments indicate the validity and sensitivity of this technology in identifying nasopharyngeal carcinoma in application.
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ISSN:0021-8979
1089-7550
DOI:10.1063/1.4993964