Outcome of young patients with rectal adenocarcinoma

• Published in: Journal of gastrointestinal oncology Vol. 8; no. 1; pp. 96 - 101
• Main Authors: Lino-Silva, Leonardo Saúl, Salcedo-Hernández, Rosa A, Ruiz-García, Erika B, León-Takahashi, Alberto M, García-Pérez, Leticia
• Format: Journal Article
• Language: English
• Published: China AME Publishing Company 01.02.2017
• Subjects: Original; adenocarcinoma; Rectal cancer; outcomes; young
• ISSN: 2078-6891; 2219-679X
• DOI: 10.21037/jgo.2016.09.04

There is an increase in the incidence of rectal carcinoma (RC) in young patients. We analyzed 175 patients with sporadic RC which were divided in two groups according their age: 24 patients ≤40 years and 151 patients >40 years and the two groups were compared in order to determine if the outcomes (especially overall 5-year survival) were different. Overall 5-year survival was similar between groups (67.1% for patients over 40 years and 70.4% for those under 40 years, P=0.803). The only differences found were in some clinicopathologic features: patients <40 years showed more dissected lymph nodes (LNs) (21 . 15, P=0.035) and more LN metastasis (54.2% . 39.1%, P=0.048). In multivariate analysis factors associated with worse survival were incomplete resection and no use of neoadjuvant therapy. Age did not demonstrate prognostic value (P=0.077). RC in people ≤40 years demonstrated greater number of LN harvested and LN metastases but oncologic outcomes, especially 5-year overall survival, were similar between groups.