Novel Taxane Diterpenoids from Taiwanese Yew Trees

Recent discovery of new and bioactive taxane diterpenoids from the roots, barks, seeds, leaves and the stems of Taxus mairei and T. sumatrana, Taiwanese yew trees are described. More than thirty new compounds including taxumatrols A and B (36, 37) have been isolated and their structures determined b...

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Bibliographic Details
Published inJournal of toxicology. Toxin reviews Vol. 22; no. 4; pp. 533 - 545
Main Authors Shen, Ya-Ching, Chang, Yao-To, Wang, Shih-Sheng, Pan, Yu-Ling, Lo, Kuang-Liang, Lin, Yu-Chi
Format Journal Article
LanguageEnglish
Published Monticello, NY Taylor & Francis 01.01.2003
Dekker
Subjects
Antitumor agents
Biological and medical sciences
Cytotoxicity
General pharmacology
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
T. sumatrana
Taxane diterpenes
taxane diterpenoids
Taxus mairei
Taxus sumatrana
Asia
Taiwan
Antineoplastic agent
Taxus
Gymnospermae
Plant origin
Diterpene
Isolation
Coniferales
Spermatophyta
Biological activity
Structural analysis
Medicinal plant
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Summary:Recent discovery of new and bioactive taxane diterpenoids from the roots, barks, seeds, leaves and the stems of Taxus mairei and T. sumatrana, Taiwanese yew trees are described. More than thirty new compounds including taxumatrols A and B (36, 37) have been isolated and their structures determined by spectroscopic analysis and chemical derivatization and correlation. Some of the isolated taxoids exhibited potent cytotoxicity against human tumor cells.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
ISSN:0731-3837
1525-6057
DOI:10.1081/TXR-120026912