Characterization of oncogene suppressor marker expression in patients with submucosal gastric carcinoma

• Published in: Molecular and clinical oncology Vol. 8; no. 3; pp. 477 - 482
• Main Authors: Moron, Roberson A, Jacob, Carlos Eduardo, Bresciani, Claudio José Caldas, Simões, Kleber, Alves, Venâncio Avancini Ferreira, Irya, Kyoshi, Gama-Rodrigues, Joaquim, Cecconello, Ivan, Longatto-Filho, Adhemar, Zilberstein, Bruno
• Format: Journal Article
• Language: English
• Published: England Spandidos Publications 01.03.2018; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Care and treatment; Development and progression; Gastric cancer; Gene expression; Genetic aspects; Health aspects; Immunoglobulins; Lymphatic system; Metastasis; Oncology; Patients; Rodents; Stomach cancer; Tumor suppressor genes; United States > US; p27kip1; p21ras; p21waf1/cip1; p16ink4a; gastric cancer; p53
• ISSN: 2049-9450; 2049-9469
• DOI: 10.3892/mco.2017.1545

The aim of the present study was to determine the clinical significance of p53 and p21 p21 , p27 and p16 expression in cases of early gastric cancer. A total of 81 patients who had undergone gastrectomy with D2 lymphadenectomy between 1971 and 2004 were retrospectively investigated. The immunohistochemical expression of p21 , p53, p21 , p27 and p16 in the tissues was evaluated. In normal, metaplastic and tumoral mucosa, p53 was positive in 53, 87.3, and 87.1% of the cases, respectively. In the same tissues, p21 was positivE in 85.3, 86 and 96.8%, respectively. Positivity FOR p16 was DETECTED IN 46.3, 91.1 and 86% OF THE CASES, respectively, WHEREAS p27 WAS positiVE IN 60, 94.7 and 95.3%, and p21 WAS positivE IN 32.4, 72.7 and 71.4% OF THE CASES, respectively. All THE tumors WERE positive for p53. Tumors with lymph node invasion presented WITH OVERexpression (+4) of p53 in 47% of the cases VS. 17% OF patients who DID not HAVE lymph node involvement. THEREFORE, higher expression of p53, p21 and p21 IN the tumor exhibited a statistically significant association with lymph node involvement.