Linking cellular metabolism and metabolomics to risk-stratification of prostate cancer clinical aggressiveness and potential therapeutic pathways

Prostate cancer treatment is based on the stratification of disease as low-, intermediate- or high-risk. This stratification has been largely based on anatomic pathology of the disease, as well as through the use of prostate specific antigen (PSA). However, despite this stratification, there remains...

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Published inTranslational andrology and urology Vol. 7; no. Suppl 4; pp. S490 - S497
Main Authors Eidelman, Eric, Tripathi, Hemantkumar, Fu, De-Xue, Siddiqui, M Minhaj
Format Journal Article
LanguageEnglish
Published China AME Publishing Company 01.09.2018
Subjects
Review
therapies, investigational
precision medicine
metabolism
Prostatic neoplasms
metabolic networks and pathways
metabolomics
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Summary:Prostate cancer treatment is based on the stratification of disease as low-, intermediate- or high-risk. This stratification has been largely based on anatomic pathology of the disease, as well as through the use of prostate specific antigen (PSA). However, despite this stratification, there remains heterogeneity within the current classification schema. Utilizing a metabolic approach may help to further establish novel biomolecular markers of disease aggressiveness. These markers may eventually be useful in not only the diagnosis of disease but in creating tumor specific targeted therapy for improved clinical outcomes.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
Contributions: (I) Conception and design: All authors; (II) Administrative support: All authors; (III) Provision of study materials or patients: All authors; (IV) Collection and assembly of data: All authors; (V) Data analysis and interpretation: All authors; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.
ISSN:2223-4691
2223-4683
2223-4691
DOI:10.21037/tau.2018.04.08