Effect of dobutamine on pulmonary gas exchange in patients with severe heart failure

Twenty patients (two female, 18 male, mean age 57 +/- 11 years) with severe heart failure NYHA IV (7 coronary artery disease, 13 congestive cardiomyopathy) were treated with 8.8 +/- 1.7 micrograms.kg-1 x min-1 of dobutamine. Pulmonary gas exchange was analysed by withdrawal of blood samples from a c...

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Bibliographic Details
Published inEuropean heart journal Vol. 13; no. 11; p. 1545
Main Authors Erlemeier, H H, Kupper, W, Bleifeld, W
Format Journal Article
LanguageEnglish
Published England 01.11.1992
Subjects
Dobutamine - pharmacology
Female
Heart Failure - drug therapy
Heart Failure - physiopathology
Hemodynamics - drug effects
Humans
Male
Middle Aged
Pulmonary Gas Exchange - drug effects
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Summary:Twenty patients (two female, 18 male, mean age 57 +/- 11 years) with severe heart failure NYHA IV (7 coronary artery disease, 13 congestive cardiomyopathy) were treated with 8.8 +/- 1.7 micrograms.kg-1 x min-1 of dobutamine. Pulmonary gas exchange was analysed by withdrawal of blood samples from a central venous catheter and a radial artery cannula. Dobutamine increased SvO2 from 58.7 +/- 11.2% to 72.2 +/- 6.3% (P = 0.0001) and decreased avDO2 from 7.7 +/- 2.45 Vol% to 4.97 +/- 1.34 Vol% (P = 0.0001). PaO2 and PaCO2 were not changed. Qs/Qt increased slightly from 9.1 +/- 8.3% to 11.3 +/- 6.4% (P = 0.035). Cardiac index increased by 51% (P = 0.0001), pulmonary capillary wedge pressure decreased by 28% (P = 0.0001). In patients with severe heart failure, dobutamine improved haemodynamics without detrimental effects on arterial oxygen concentration.
ISSN:0195-668X
DOI:10.1093/oxfordjournals.eurheartj.a060099