Imaging of malignant pleural mesothelioma: it is possible a screening or early diagnosis program?—a systematic review about the use of screening programs in a population of asbestos exposed workers

Malignant pleural mesothelioma (MPM) in an uncommon neoplasia with high mortality rate, mostly related to professional asbestos exposure. Clinical manifestations are not specific so that diagnosis is performed at advanced stage and screening protocols are not feasible now. On the other hand, asbesto...

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Published inJournal of thoracic disease Vol. 10; no. S2; pp. S262 - S268
Main Authors Falaschi, Fabio, Romei, Chiara, Fiorini, Sara, Lucchi, Marco
Format Journal Article
LanguageEnglish
Published China AME Publishing Company 01.01.2018
Subjects
Review
lung cancer
Mesothelioma
screening
asbestos exposed workers
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Summary:Malignant pleural mesothelioma (MPM) in an uncommon neoplasia with high mortality rate, mostly related to professional asbestos exposure. Clinical manifestations are not specific so that diagnosis is performed at advanced stage and screening protocols are not feasible now. On the other hand, asbestos-exposed workers have a high incidence of developing lung cancer. Low-dose computed tomography (LDCT) is a volumetric acquisition technique with high spatial resolution and a low dose exposure; it is used in many trials to detect lung tumours at an early stage in screening protocols, reducing mortality rate in smoker subjects. In recent papers, the possibly role of lung cancer screening was evaluated and recommended also in subjects exposed to asbestos. This article summarizes previous and present clinical trials validated for lung cancer screening, to discuss the possibility of early diagnosis or screening programs in a population of asbestos exposed workers by LDCT.
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Contributions: (I) Conception and design: F Falaschi; (II) Administrative support: C Romei, S Fiorini; (III) Provision of study materials or patients: F Falaschi, M Lucchi; (IV) Collection and assembly of data: F Falaschi, C Romei, S Fiorini; (V) Data analysis and interpretation: F Falaschi; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.
ISSN:2072-1439
2077-6624
DOI:10.21037/jtd.2017.12.57