Double or triple antithrombotic combination therapy in patients who need anticoagulation and antiplatelet therapy in parallel

The optimal strategy to balance bleeding and ischaemic events in patients with atrial fibrillation, requiring antiplatelet therapy on top of anticoagulation, is subject to debate, since specifically designed and powered randomized trials are not available yet. The review aims to highlight the curren...

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Published inEuropean heart journal. Cardiovascular pharmacotherapy Vol. 1; no. 3; pp. 191 - 197
Main Authors Rohla, Miklos, Weiss, Thomas W., Wojta, Johann, Niessner, Alexander, Huber, Kurt
Format Journal Article Book Review
LanguageEnglish
Published England Oxford University Press 01.07.2015
Subjects
Anticoagulants - therapeutic use
Atrial Fibrillation - complications
Atrial Fibrillation - drug therapy
Drug Therapy, Combination
Fibrinolytic Agents - therapeutic use
Humans
Risk Factors
Thrombolytic Therapy - methods
Thrombosis - etiology
Thrombosis - prevention & control
Antithrombotic therapy
Coronary stenting
Atrial fibrillation
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Summary:The optimal strategy to balance bleeding and ischaemic events in patients with atrial fibrillation, requiring antiplatelet therapy on top of anticoagulation, is subject to debate, since specifically designed and powered randomized trials are not available yet. The review aims to highlight the current developments in the light of the 2014 joint consensus document of the European Society of Cardiology (ESC) Working Group on Thrombosis, European Heart Rhythm Association (EHRA), European Association of Percutaneous Cardiovascular Interventions (EAPCI), and European Association of Acute Cardiac Care (ACCA) endorsed by the Heart Rhythm Society (HRS) and Asia-Pacific Heart Rhythm Society (APHRS) and of the 2014 ESC myocardial revascularization guidelines, both published recently.
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ISSN:2055-6837
2055-6845
DOI:10.1093/ehjcvp/pvv014