IgE-type antibodies to Ascaris antigens in man

IgE antibodies to Ascaris antigens were detected by radioallergosorbent test (RAST) in the serum obtained from a person experimentally sensitized with Ascaris suum antigens prepared from the body fluid of worms. This serum passively sensitized human skin in vitro and histamine release from the sensi...

Full description

Saved in:
Bibliographic Details
Published inInternational archives of allergy and applied immunology Vol. 55; no. 1-6; p. 78
Main Authors Tsuji, M, Hayashi, T, Yamamoto, S, Sakata, Y, Toshida, T
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1977
Subjects
Antibody Formation
Antigen-Antibody Reactions
Ascaris - immunology
Epitopes
Histamine Release
Humans
Immunoglobulin E
Male
Radioallergosorbent Test
Skin - immunology
Online AccessGet more information

Cover

More Information
Summary:IgE antibodies to Ascaris antigens were detected by radioallergosorbent test (RAST) in the serum obtained from a person experimentally sensitized with Ascaris suum antigens prepared from the body fluid of worms. This serum passively sensitized human skin in vitro and histamine release from the sensitized skin was observed by challenge with antigens. The allergenicity of A. suum antigens was present over a very broad spectrum of molecular size. The present results suggest that specific IgE antibodies to Ascaris antigens might be in Ascaris-infected patients and allergic symptoms which belong to type 1 reaction might be mediated by IgE in these patients.
ISSN:0020-5915
DOI:10.1159/000231912