Diagnostic and prognostic value of cardiac imaging in amyloidosis

Amyloidosis is an infiltrative disease caused by extracellular protein deposition that has accumulated a lot of scientific production in recent years. Different types of amyloidosis can affect the heart. Transthyretin amyloidosis and light chain amyloidosis are the two most common types of cardiac a...

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Published inWorld journal of cardiology Vol. 12; no. 12; pp. 599 - 614
Main Authors Vidal-Perez, Rafael, Vázquez-García, Raquel, Barge-Caballero, Gonzalo, Bouzas-Mosquera, Alberto, Soler-Fernandez, Rafaela, Larrañaga-Moreira, Jose Maria, Crespo-Leiro, Maria Generosa, Vazquez-Rodriguez, Jose Manuel
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 26.12.2020
Subjects
Minireviews
Immunoglobulin light-chain amyloidosis
Echocardiography
Magnetic resonance imaging
Transthyretin cardiac amyloidosis
Nuclear imaging
Cardiac imaging techniques
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Summary:Amyloidosis is an infiltrative disease caused by extracellular protein deposition that has accumulated a lot of scientific production in recent years. Different types of amyloidosis can affect the heart. Transthyretin amyloidosis and light chain amyloidosis are the two most common types of cardiac amyloidosis. These entities have a poor prognosis, so accurate diagnostic techniques are imperative for determining an early therapeutic approach. Recent advances in cardiac imaging and diagnostic strategies show that these tools are safe and can avoid the use of invasive diagnostic techniques to histological confirmation, such as endomyocardial biopsy. We performed a review on the diagnostic and prognostic implications of different cardiac imaging techniques in cardiac amyloidosis. We mainly focus on reviewing echocardiography, cardiac magnetic resonance, computed tomography and nuclear imaging techniques and the different safety measurements that can be done with each of them.
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Corresponding author: Raquel Vázquez-García, MD, Staff Physician, Servicio de Cardiología, Complexo Hospitalario Universitario A Coruña (CHUAC), As Xubias de Arriba-84, A Coruña 15006, A Coruña, Spain. raquelvazquezgarcia@outlook.com
Author contributions: Vidal-Perez R and Vázquez-García R contributed equally to this work; Vidal-Perez R and Vázquez-García R designed, performed the collection of the data, edited and wrote the paper; Barge-Caballero G, Bouzas-Mosquera A, Soler-Fernandez R, Larrañaga-Moreira JM, Crespo-Leiro MG and Vazquez-Rodriguez JM contributed to the critical revision and editing of the paper.
ISSN:1949-8462
1949-8462
DOI:10.4330/wjc.v12.i12.599