DRD4 and novelty seeking: results of meta-analyses

Studies of the association between polymorphisms within and near the dopamine D4 receptor (DRD4) gene and novelty seeking (NS) have produced inconsistent results, raising questions about the strength of the relationship and the methodological conditions under which the relationship holds. We conduct...

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Bibliographic Details
Published inAmerican journal of medical genetics Vol. 114; no. 6; p. 643
Main Authors Schinka, J A, Letsch, E A, Crawford, F C
Format Journal Article
LanguageEnglish
Published United States 08.08.2002
Subjects
Adult
Analysis of Variance
Exons
Exploratory Behavior
Female
Gene Frequency
Genotype
Humans
Male
Minisatellite Repeats
Personality - genetics
Polymorphism, Genetic
Receptors, Dopamine D2 - genetics
Receptors, Dopamine D4
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Summary:Studies of the association between polymorphisms within and near the dopamine D4 receptor (DRD4) gene and novelty seeking (NS) have produced inconsistent results, raising questions about the strength of the relationship and the methodological conditions under which the relationship holds. We conducted three meta-analyses of existing studies to provide formal statistical measures of the strength of the DRD4-NS relationship. Results provided no support for a relationship between NS and the presence of the 7-repeat allele of the VNTR polymorphism. A small positive effect, however, was found for long repeats of the same polymorphism. The most promising findings were obtained for the relationship with the -521 C/T promoter polymorphism, for which the analysis showed an effect size of 0.32. The positive findings are consistent with a polygenic model of influence on fundamental personality dimensions.
ISSN:0148-7299
DOI:10.1002/ajmg.10649