Mechanisms Protecting Acinetobacter baumannii against Multiple Stresses Triggered by the Host Immune Response, Antibiotics and Outside-Host Environment

• Published in: International journal of molecular sciences Vol. 21; no. 15; p. 5498
• Main Authors: Monem, Soroosh, Furmanek-Blaszk, Beata, Łupkowska, Adrianna, Kuczyńska-Wiśnik, Dorota, Stojowska-Swędrzyńska, Karolina, Laskowska, Ewa
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 31.07.2020; MDPI
• Subjects: Acinetobacter baumannii; Acinetobacter baumannii - genetics; Acinetobacter baumannii - pathogenicity; Acinetobacter Infections - genetics; Acinetobacter Infections - immunology; Acinetobacter Infections - microbiology; Anti-Bacterial Agents - therapeutic use; Antibiotics; Antimicrobial resistance; Bacteria; Bacterial infections; biofilm; Biofilms; Biofilms - growth & development; Desiccation; desiccation stress; Drug Resistance, Multiple, Bacterial - genetics; Gram-negative bacteria; Heterogeneity; Host-Pathogen Interactions - genetics; Humans; Immune response; Immune system; Immunity - genetics; Infections; Morbidity; Multidrug resistance; Multidrug resistant organisms; Neutrophils; Nosocomial infection; Pathogens; Peptides; persisters; proteostasis; Review; Signal transduction; Strains (organisms); Tumor necrosis factor-TNF; Virulence; Virulence - genetics; multidrug resistance; persisters; Acinetobacter baumannii; proteostasis; desiccation stress; biofilm
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms21155498

is considered one of the most persistent pathogens responsible for nosocomial infections. Due to the emergence of multidrug resistant strains, as well as high morbidity and mortality caused by this pathogen, was placed on the World Health Organization (WHO) drug-resistant bacteria and antimicrobial resistance research priority list. This review summarizes current studies on mechanisms that protect against multiple stresses caused by the host immune response, outside host environment, and antibiotic treatment. We particularly focus on the ability of to survive long-term desiccation on abiotic surfaces and the population heterogeneity in biofilms. Insight into these protective mechanisms may provide clues for the development of new strategies to fight multidrug resistant strains of .