Immunoglobulin E sialylation regulates allergic responses

Shade et al. demonstrate that people with peanut allergies produce IgE antibodies that are enriched for sialic acid-containing glycoforms. The sialylated IgE triggered significantly more degranulation by basophils and mast cells, suggesting intrinsic functional differences between IgEs from allergic...

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Bibliographic Details
Published inImmunology and cell biology Vol. 98; no. 8; p. 617
Main Authors Xie, Markus M, Bertozzi, Carolyn R, Wang, Taia T
Format Journal Article
LanguageEnglish
Published United States 01.09.2020
Subjects
Basophils
Humans
Immunoglobulin E
Mast Cells
Peanut Hypersensitivity
Virulence
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Summary:Shade et al. demonstrate that people with peanut allergies produce IgE antibodies that are enriched for sialic acid-containing glycoforms. The sialylated IgE triggered significantly more degranulation by basophils and mast cells, suggesting intrinsic functional differences between IgEs from allergic and nonallergic subjects.
ISSN:1440-1711
DOI:10.1111/imcb.12368