Cell compartmentalization in redox signaling

From a growing body of evidence on the role of Reactive Oxygen Species as intracellular signaling molecules, the concept starts to emerge that cell responses to redox changes are function of the intracellular site where oxidants are produced and/or meet their molecular targets. In particular, a majo...

Full description

Saved in:
Bibliographic Details
Published inIUBMB life Vol. 52; no. 1-2; p. 7
Main Authors Pani, G, Bedogni, B, Colavitti, R, Anzevino, R, Borrello, S, Galeotti, T
Format Journal Article
LanguageEnglish
Published England 01.07.2001
Subjects
Animals
Apoptosis
Cell Compartmentation
Cell Respiration
Cellular Senescence
Humans
Mitochondria - metabolism
NADPH Oxidases - metabolism
Oxidation-Reduction
Oxidative Stress
ras Proteins - metabolism
Signal Transduction
Superoxides - metabolism
Tumor Necrosis Factor-alpha - metabolism
Online AccessGet more information

Cover

More Information
Summary:From a growing body of evidence on the role of Reactive Oxygen Species as intracellular signaling molecules, the concept starts to emerge that cell responses to redox changes are function of the intracellular site where oxidants are produced and/or meet their molecular targets. In particular, a major distinction between oxidative events in the cytosolic versus the mitochondrial compartment appears to exist in terms of physiological stimuli, signaling mechanisms and functional consequences. Experimental data supporting this view are reviewed here, and the potential implications of this new perspective in redox signaling are discussed.
ISSN:1521-6543
DOI:10.1080/15216540252774702