Does drug-induced sleep endoscopy affect surgical outcome? A multicenter study of 326 obstructive sleep apnea patients

• Published in: The Laryngoscope Vol. 130; no. 2; p. 551
• Main Authors: Pang, Kenny P, Baptista, Peter M, Olszewska, Ewa, Braverman, Itzhak, Carrasco-Llatas, Marina, Kishore, Srivinas, Chandra, Sudipta, Yang, Hyung Chae, Wang, Cybil Mei Zhi, Chan, Yiong Huak, Pang, Kathleen A, Pang, Edward B, Rotenberg, Brian
• Format: Journal Article
• Language: English
• Published: United States 01.02.2020
• Subjects: Endoscopy - methods; Female; Humans; Hypnotics and Sedatives - pharmacology; Male; Middle Aged; Prospective Studies; Sleep - drug effects; Sleep Apnea, Obstructive - surgery; obstructive sleep apnea; success rate; Drug-induced sleep endoscopy
• ISSN: 1531-4995
• DOI: 10.1002/lary.27987

Our objective was to determine whether drug-induced sleep apnea (DISE) affects the successfulness of the surgical outcome. Prospective, seven-country, nonrandomized trial. There were 326 consecutive obstructive sleep apnea (OSA) patients who had nose, palate, and/or tongue surgery included in the study. DISE was performed in only one group. There were 170 patients in the DISE group and 156 patients in no-DISE group. The mean preoperative body mass index (BMI) for the DISE group was 27.6 ± 4.6, whereas in the no-DISE group it was 28.1 ± 3.9 (P = .23). The mean preoperative systolic blood pressure (SBP) for the DISE group was 130.4 ± 16.7, whereas in the no-DISE group it was 142.9 ± 15.5 (P < .001). The mean preoperative diastolic blood pressure (DBP) for the DISE group was 81.4 ± 9.7, whereas in the no-DISE group it was 89.1 ± 9.7 (P < .001). The mean preoperative apnea-hypopnea index (AHI) for the DISE group was 32.6 ± 18.8, whereas in the no-DISE group it was 33.7 ± 19.6 (P = .61). The mean postoperative AHI for the DISE group was 15.9 ± 12.6, whereas in the no-DISE group it was 13.2 ± 8.8 (P = .023). The age-, gender-, BMI-adjusted percentage change in AHI for the DISE group was -48.4 ± 31.9, whereas in the no-DISE group it was -59.8 ± 18.6 (P < .001). The age-, gender-, and BMI-adjusted success rate for the DISE group was 66.5%, whereas in the no-DISE group it was 80.8% (P = .004). The age-, gender-, and BMI-adjusted change in SBP for the DISE group was -6.1 ± 8.6, whereas in the no-DISE group it was -13.3 ± 11.1 (P < .001). The age-, gender-, and BMI-adjusted change in DBP in the DISE group was -5.2 ± 12.1, whereas in the no-DISE group it was -12.4 ± 11.7 (P < .001). The mean age- and gender-adjusted change in BMI for the DISE group was -4.6 ± 12.9, whereas in the no-DISE group it was -6.3 ± 18.5 (P = .34). The Cohen effect of BMI on the overall AHI, lowest oxygen saturation, and blood pressure changes was 0.08. DISE may not significantly affect surgical success in OSA. 2c Laryngoscope, 130:551-555, 2020.