The effect of propranolol on catecholamine clearance

Normal subjects given propranolol increased their plasma t1/2 for infused isoproterenol from 2.68 to 6.25 minutes. Propranolol increased plasma norepinephrine (NE) levels only slightly. Propranolol increased the t1/2 of isoproterenol but not that of NE in men with autonomic nervous system degenerati...

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Bibliographic Details
Published inClinical pharmacology and therapeutics Vol. 40; no. 1; p. 116
Main Authors Ziegler, M G, Chernow, B, Woodson, L C, Coyle, J, Cruess, D, Lake, C R
Format Journal Article
LanguageEnglish
Published United States 01.07.1986
Subjects
Blood Pressure - drug effects
Drug Interactions
Half-Life
Humans
Hypertension - drug therapy
Isoproterenol - metabolism
Isoproterenol - pharmacology
Norepinephrine - blood
Physical Exertion
Propranolol - pharmacology
Propranolol - therapeutic use
Pulse - drug effects
Shy-Drager Syndrome - drug therapy
Shy-Drager Syndrome - metabolism
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Summary:Normal subjects given propranolol increased their plasma t1/2 for infused isoproterenol from 2.68 to 6.25 minutes. Propranolol increased plasma norepinephrine (NE) levels only slightly. Propranolol increased the t1/2 of isoproterenol but not that of NE in men with autonomic nervous system degeneration. This suggests that propranolol acts on nonneuronal uptake-2 processes, rather than on uptake-1 mechanisms. alpha-Blockers slow uptake-1 and beta-blockers slow uptake-2 processes. When 27 subjects exercised, those who attained the highest plasma levels of the alpha- and beta-receptor agonist NE also had the briefest apparent t1/2 for NE. Adrenergic receptor blocking drugs slow catecholamine clearance. NE may stimulate its own clearance.
ISSN:0009-9236
DOI:10.1038/clpt.1986.147