Reye's syndrome developing in an infant on treatment of Kawasaki syndrome
: Aspirin is commonly used as an anti‐inflammatory therapy for Kawasaki syndrome. Early initiation with high dose aspirin (80 to >100 mg/kg per day), followed by low‐dose therapy at the afebrile stage, has been often used to reduce morbidity and mortality in coronary complications. We report a 1...
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Published in | Journal of paediatrics and child health Vol. 41; no. 5‐6; pp. 303 - 304 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
PO Box 378 , Carlton South Victoria 3053 , Australia
Blackwell Science Pty
01.05.2005
Blackwell Publishing Ltd |
Subjects | |
Online Access | Get full text |
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Summary: | : Aspirin is commonly used as an anti‐inflammatory therapy for Kawasaki syndrome. Early initiation with high dose aspirin (80 to >100 mg/kg per day), followed by low‐dose therapy at the afebrile stage, has been often used to reduce morbidity and mortality in coronary complications. We report a 10‐month‐old infant who was diagnosed with Kawasaki syndrome. Sudden onset of poor activity, poor appetite, lethargy, tachycardia, tachypnea, hepatomegaly, increased AST/ALT, coagulopathy and hyperammonemia developed 3 days after the high‐dose aspirin therapy. His histopathological and ultrastructural findings from the liver biopsy were compatible with Reye's syndrome. He recovered completely, and there was no recurrence. |
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ISSN: | 1034-4810 1440-1754 |
DOI: | 10.1111/j.1440-1754.2005.00617.x |