Molecular Mechanism of Induction of Bone Growth by the C-Type Natriuretic Peptide

• Published in: International journal of molecular sciences Vol. 23; no. 11; p. 5916
• Main Authors: Rintz, Estera, Węgrzyn, Grzegorz, Fujii, Toshihito, Tomatsu, Shunji
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.05.2022; MDPI
• Subjects: Autocrine signalling; Blood pressure; Bone Development; Bone growth; Bone marrow; C-Type natriuretic peptide; Cardiovascular system; Cartilage; chondrocyte cell; Chondrocytes; Chondrocytes - metabolism; Endochondral bone; Endothelium; Enzymes; Fibroblasts; Growth plate; Growth Plate - metabolism; Heart; Hormones; Ligands; Mineralization; molecular mechanism; natriuretic peptide; Natriuretic Peptide, C-Type - metabolism; Nitric oxide; Organs; Ossification; Osteogenesis; Paracrine signalling; Peptide hormones; Peptides; Phosphatase; Review; molecular mechanism; natriuretic peptide; bone growth; chondrocyte cell; growth plate
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms23115916

The skeletal development process in the body occurs through sequential cellular and molecular processes called endochondral ossification. Endochondral ossification occurs in the growth plate where chondrocytes differentiate from resting, proliferative, hypertrophic to calcified zones. Natriuretic peptides (NPTs) are peptide hormones with multiple functions, including regulation of blood pressure, water-mineral balance, and many metabolic processes. NPTs secreted from the heart activate different tissues and organs, working in a paracrine or autocrine manner. One of the natriuretic peptides, C-type natriuretic peptide-, induces bone growth through several mechanisms. This review will summarize the knowledge, including the newest discoveries, of the mechanism of CNP activation in bone growth.