Diagnostic performance of shear wave measurement in the detection of hepatic fibrosis: A multicenter prospective study

• Published in: Hepatology research Vol. 54; no. 9; pp. 851 - 858
• Main Authors: Kumada, Takashi, Toyoda, Hidenori, Ogawa, Sadanobu, Gotoh, Tatsuya, Yoshida, Yuichi, Yamahira, Masahiro, Hirooka, Masashi, Koizumi, Yohei, Hiasa, Yoichi, Tamai, Tsutomu, Kuromatsu, Ryoko, Matsuzaki, Toshihisa, Suehiro, Tomoyuki, Kamada, Yoshihiro, Sumida, Yoshio, Tanaka, Junko, Shimizu, Masahito
• Format: Journal Article
• Language: English
• Published: Netherlands Wiley Subscription Services, Inc 01.09.2024
• Subjects: area under the receiver operating characteristic curve; Body mass index; Cirrhosis; correlation coefficient; Fibrosis; Liver cirrhosis; Liver diseases; liver stiffness; magnetic resonance elastography; shear wave measurement; liver stiffness; area under the receiver operating characteristic curve; shear wave measurement; magnetic resonance elastography; correlation coefficient
• ISSN: 1386-6346; 1872-034X
• DOI: 10.1111/hepr.14026

Aim This study aimed to establish the shear wave measurement (SWM) cut‐off value for each fibrosis stage using magnetic resonance (MR) elastography values as a reference standard. Methods We prospectively analyzed 594 patients with chronic liver disease who underwent SWM and MR elastography. Correlation coefficients (were analyzed, and the diagnostic value was evaluated by the area under the receiver operating characteristic curve. Liver stiffness was categorized by MR elastography as F0 (<2.61 kPa), F1 (≥2.61 kPa, <2.97 kPa, any fibrosis), F2 (≥2.97 kPa, <3.62 kPa, significant fibrosis), F3 (≥3.62 kPa, <4.62 kPa, advanced fibrosis), or F4 (≥4.62 kPa, cirrhosis). Results The median SWM values increased significantly with increasing fibrosis stage (p < 0.001). The correlation coefficient between SWM and MR elastography values was 0.793 (95% confidence interval 0.761–0.821). The correlation coefficients between SWM and MR elastography values significantly decreased with increasing body mass index and skin–capsular distance; skin–capsular distance values were associated with significant differences in sensitivity, specificity, accuracy, or positive predictive value, whereas body mass index values were not. The best cut‐off values for any fibrosis, significant fibrosis, advanced fibrosis, and cirrhosis were 6.18, 7.09, 8.05, and 10.89 kPa, respectively. Conclusions This multicenter study in a large number of patients established SWM cut‐off values for different degrees of fibrosis in chronic liver diseases using MR elastography as a reference standard. It is expected that these cut‐off values will be applied to liver diseases in the future. The correlation coefficient between shear wave measurement and magnetic resonance elastography values was 0.793 (95% confidence interval 0.761–0.821), indicating a strong correlation. The correlation coefficients between shear wave measurement and magnetic resonance elastography values decreased significantly with increasing body mass index and skin capsular distance, and skin–capsular distance values were associated with significant differences in sensitivity, specificity, accuracy, or positive predictive value, whereas body mass index values were not. We established shear wave measurement cut‐off values for different degrees of fibrosis in chronic liver diseases using magnetic resonance elastography as a reference standard.