Unravelling the complexity of enzyme catalysis

• Published in: The FEBS journal Vol. 290; no. 9; pp. 2204 - 2207
• Main Author: Scrutton, Nigel S.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.05.2023
• Subjects: Biomedical engineering; Catalysis; Catalytic activity; Complexity; drug discovery; enzyme kinetics; Enzymes; Enzymes - chemistry; Enzymes - genetics; Enzymology; Exploitation; Macromolecules; phosphorylation; Thermodynamics; thermodynamics; catalysis; enzymes; drug discovery; phosphorylation; enzyme kinetics
• ISSN: 1742-464X; 1742-4658
• DOI: 10.1111/febs.16796

The study of enzymes never disappoints. Despite its long history—almost 150 years following the first documented use of the word enzyme in 1878—the field of enzymology advances apace. This long journey has witnessed landmark developments that have defined modern enzymology as a broad discipline, leading to improved understanding at the molecular level, as we aspire to discover the complex relationships between enzyme structures, catalytic mechanisms and biological function. How enzymes are regulated at the gene and post‐translational levels and how catalytic activity is modulated by interactions with small ligands and macromolecules, or the broader enzyme environment, are topical areas of study. Insights from such studies guide the exploitation of natural and engineered enzymes in biomedical or industrial processes; for example, in diagnostics, pharmaceuticals manufacture and processing technologies that use immobilised enzymes and enzyme reactor‐based systems. In this Focus Issue, The FEBS Journal seeks to highlight breaking science and informative reviews, as well as personal reflections, to illustrate the breadth and importance of contemporary molecular enzymology research. The field of enzymology has witnessed landmark developments that have led to its improved understanding at the molecular level and to the discovery of complex relationships between enzyme structures, catalytic mechanisms and biological function. How enzymes are regulated at the gene and post‐translational levels and how catalytic activity is controlled are topical areas of the study. Here, Nigel Scrutton introduces The FEBS Journal's Focus Issue on Enzymes, which features breaking science and informative reviews, as well as personal reflections, and illustrates the breadth and importance of contemporary molecular enzymology research.