Etiology of Idiopathic Scoliosis: Current Trends in Research

Current population studies characterize idiopathic scoliosis as a single-gene disorder that follows the patterns of mendelian genetics, including variable penetrance and heterogeneity. The role of melatonin and calmodulin in the development of idiopathic scoliosis is likely secondary, with indirect...

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Published inJournal of bone and joint surgery. American volume Vol. 82; no. 8; p. 1157
Main Authors Lowe, Thomas G, Edgar, Michael, Margulies, Joseph Y, Miller, Nancy H, Raso, V James, Reinker, Kent A, Rivard, Charles-Hilaire
Format Journal Article
LanguageEnglish
Published Boston, MA Copyright by The Journal of Bone and Joint Surgery, Incorporated 01.08.2000
Journal of Bone and Joint Surgery Incorporated
Journal of Bone and Joint Surgery AMERICAN VOLUME
EditionAmerican volume
Subjects
Biological and medical sciences
Biomechanical Phenomena
Blood Platelets - pathology
Diseases of the osteoarticular system
Diseases of the spine
Growth
Humans
Medical sciences
Melatonin - physiology
Models, Theoretical
Muscle, Skeletal - abnormalities
Pedigree
Scoliosis - etiology
Scoliosis - genetics
Human
Puberty
Melatonin
Deformation
Pathogenesis
Spine
Aminoacid derivative hormone
Diseases of the osteoarticular system
Idiopathic
Spine disease
Biomechanics
Etiology
Scoliosis
Adolescent
Hormonal regulation
Genetics
Mathematical model
Calmodulin
Pineal hormone
Growth factor
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Summary:Current population studies characterize idiopathic scoliosis as a single-gene disorder that follows the patterns of mendelian genetics, including variable penetrance and heterogeneity. The role of melatonin and calmodulin in the development of idiopathic scoliosis is likely secondary, with indirect effects on growth mechanisms. Reported abnormalities of connective tissue, skeletal muscle, platelets, the spinal column, and the rib cage are all thought to be secondary to the deformity itself. Although no consistent neurological abnormalities have been identified in patients with idiopathic scoliosis, it is possible that a defect in processing by the central nervous system affects the growing spine. The true etiology of idiopathic scoliosis remains unknown; however, it appears to be multifactorial.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0021-9355
1535-1386
DOI:10.2106/00004623-200008000-00014