Viral interference in HIV-1 infected cells

• Published in: Reviews in medical virology Vol. 8; no. 4; pp. 203 - 211
• Main Authors: Potash, Mary Jane, Volsky, David J.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Ltd 01.10.1998; Wiley Periodicals Inc
• Subjects: Human immunodeficiency virus 1
• ISSN: 1052-9276; 1099-1654; 1099-1654
• DOI: 10.1002/(SICI)1099-1654(1998100)8:4<203::AID-RMV224>3.0.CO;2-#

The study of viral interference in HIV‐1 infected cells has revealed several different means whereby infected cells resist superinfection. The most familiar of these, down‐modulation of cellular receptors for virus, can be accomplished through the independent action of at least three HIV‐1 proteins. Both the principal viral receptor CD4 and the chemokine receptors which serve as co‐receptors are subject to down‐modulation as a consequence of infection. Elucidation of the specificity of co‐receptor utilisation by HIV‐1 strains is an exciting, ongoing task which has opened new avenues to the understanding of viral replication and pathogenesis. Novel routes to resistance to superinfection have been discovered during HIV‐1 infection and their investigation may reveal new pathways to control HIV‐1 and the loss of immunological function with AIDS. Copyright © 1998 John Wiley & Sons, Ltd.