Ophiobolin Sesterterpenoids and Pyrrolidine Alkaloids from the Sponge-Derived Fungus Aspergillus ustus

Chemical examination of the fungus Aspergillus ustus isolated from the Mediterranean sponge Suberites domuncula yielded the five new ophiobolin‐type sesterterpenoids 1–5 and the two new pyrrolidine alkaloids 6 and 7, together with the known compound aurantiamine and cerebroside D. The structures of...

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Published inHelvetica chimica acta Vol. 94; no. 4; pp. 623 - 631
Main Authors Liu, Hong-Bing, Edrada-Ebel, RuAngelie, Ebel, Rainer, Wang, Yao, Schulz, Barbara, Draeger, Siegfried, Müller, Werner E. G., Wray, Victor, Lin, Wen-Han, Proksch, Peter
Format Journal Article
LanguageEnglish
Published Zürich WILEY-VCH Verlag 01.04.2011
WILEY‐VCH Verlag
Wiley
Subjects
Alkaloids
Aspergillus ustus
Chemistry
Chemistry, Multidisciplinary
Cytotoxic activity
Fungi
Physical Sciences
Pyrrolidine alkaloids
Science & Technology
Sesterterpenoids
Suberites domuncula
MARINE
METABOLITES
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Summary:Chemical examination of the fungus Aspergillus ustus isolated from the Mediterranean sponge Suberites domuncula yielded the five new ophiobolin‐type sesterterpenoids 1–5 and the two new pyrrolidine alkaloids 6 and 7, together with the known compound aurantiamine and cerebroside D. The structures of the new compounds were unambiguously elucidated on the basis of extensive spectroscopic‐data analysis (1D‐ and 2D‐NMR, MS, and UV) and comparison with literature data. All compounds were evaluated for their cytotoxicity against murine lymphoma cell line L5178Y.
Bibliography:istex:60AE2C1D7AA5C07DF7606ABF1BA56DB90C9081A7
ArticleID:HLCA201000283
ark:/67375/WNG-W38NQ730-V
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201000283