Oncogenic effects of exosomes in γ‐herpesvirus‐associated neoplasms

Kaposi's sarcoma‐associated herpesvirus (KSHV) and Epstein–Barr virus (EBV) are herpesviruses associated with human malignancies. As exosomes can shuttle many herpesvirus‐associated biomolecules from host cells to recipient cells, the exosomal pathway is utilized by herpesviruses to achieve ext...

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Published inJournal of cellular physiology Vol. 234; no. 11; pp. 19167 - 19179
Main Authors Zheng, Jiayu, Shi, Yiwan, Feng, Zhenyu, Zheng, Yilu, Li, Zhanhao, Zhao, Yi, Wang, Yan
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.11.2019
Subjects
Biomolecules
Carcinogenesis - genetics
Cell Transformation, Neoplastic - genetics
Diagnostic systems
EBV
Epstein-Barr virus
exosome
Exosomes
Exosomes - genetics
Exosomes - virology
Herpes viruses
Herpesvirus 4, Human - genetics
Herpesvirus 4, Human - pathogenicity
Herpesvirus 8, Human - genetics
Herpesvirus 8, Human - pathogenicity
Humans
Kaposi's sarcoma
KSHV
Neoplasms
Neoplasms - genetics
Neoplasms - pathology
Neoplasms - virology
Sarcoma
Signal processing
Therapeutic applications
Tumorigenesis
Viruses
EBV
neoplasms
KSHV
exosome
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Abstract Kaposi's sarcoma‐associated herpesvirus (KSHV) and Epstein–Barr virus (EBV) are herpesviruses associated with human malignancies. As exosomes can shuttle many herpesvirus‐associated biomolecules from host cells to recipient cells, the exosomal pathway is utilized by herpesviruses to achieve extensive infections and even oncogenesis. In this review, we discuss the oncogenic biomolecules present in exosomes derived from KSHV‐ and EBV‐infected cells. Moreover, oncogenesis via exosomal biomolecules mainly occurs through three processes, including regulation of downstream signals, promotion of immune dysfunction and transformation of cells. Also, the exosomes may provide diagnostic markers and therapeutic targets specific for KSHV‐ and EBV‐associated malignancies. Kaposi's sarcoma‐associated herpesvirus (KSHV)‐ and Epstein–Barr virus (EBV)‐associated exosomes manipulate the extracellular environment leading to neoplasm progression. Regulation of downstream signals, promotion of immune dysfunction and transformation of cells are three major bioeffects of KSHV‐ and EBV‐associated exosomes.
AbstractList Kaposi's sarcoma‐associated herpesvirus (KSHV) and Epstein–Barr virus (EBV) are herpesviruses associated with human malignancies. As exosomes can shuttle many herpesvirus‐associated biomolecules from host cells to recipient cells, the exosomal pathway is utilized by herpesviruses to achieve extensive infections and even oncogenesis. In this review, we discuss the oncogenic biomolecules present in exosomes derived from KSHV‐ and EBV‐infected cells. Moreover, oncogenesis via exosomal biomolecules mainly occurs through three processes, including regulation of downstream signals, promotion of immune dysfunction and transformation of cells. Also, the exosomes may provide diagnostic markers and therapeutic targets specific for KSHV‐ and EBV‐associated malignancies. Kaposi's sarcoma‐associated herpesvirus (KSHV)‐ and Epstein–Barr virus (EBV)‐associated exosomes manipulate the extracellular environment leading to neoplasm progression. Regulation of downstream signals, promotion of immune dysfunction and transformation of cells are three major bioeffects of KSHV‐ and EBV‐associated exosomes.
Kaposi's sarcoma‐associated herpesvirus (KSHV) and Epstein–Barr virus (EBV) are herpesviruses associated with human malignancies. As exosomes can shuttle many herpesvirus‐associated biomolecules from host cells to recipient cells, the exosomal pathway is utilized by herpesviruses to achieve extensive infections and even oncogenesis. In this review, we discuss the oncogenic biomolecules present in exosomes derived from KSHV‐ and EBV‐infected cells. Moreover, oncogenesis via exosomal biomolecules mainly occurs through three processes, including regulation of downstream signals, promotion of immune dysfunction and transformation of cells. Also, the exosomes may provide diagnostic markers and therapeutic targets specific for KSHV‐ and EBV‐associated malignancies.
Abstract Kaposi's sarcoma‐associated herpesvirus (KSHV) and Epstein–Barr virus (EBV) are herpesviruses associated with human malignancies. As exosomes can shuttle many herpesvirus‐associated biomolecules from host cells to recipient cells, the exosomal pathway is utilized by herpesviruses to achieve extensive infections and even oncogenesis. In this review, we discuss the oncogenic biomolecules present in exosomes derived from KSHV‐ and EBV‐infected cells. Moreover, oncogenesis via exosomal biomolecules mainly occurs through three processes, including regulation of downstream signals, promotion of immune dysfunction and transformation of cells. Also, the exosomes may provide diagnostic markers and therapeutic targets specific for KSHV‐ and EBV‐associated malignancies.
Author Shi, Yiwan
Zheng, Jiayu
Feng, Zhenyu
Zhao, Yi
Li, Zhanhao
Zheng, Yilu
Wang, Yan
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Keywords EBV
neoplasms
KSHV
exosome
Language English
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Snippet Kaposi's sarcoma‐associated herpesvirus (KSHV) and Epstein–Barr virus (EBV) are herpesviruses associated with human malignancies. As exosomes can shuttle many...
Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) are herpesviruses associated with human malignancies. As exosomes can shuttle many...
Abstract Kaposi's sarcoma‐associated herpesvirus (KSHV) and Epstein–Barr virus (EBV) are herpesviruses associated with human malignancies. As exosomes can...
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SubjectTerms Biomolecules
Carcinogenesis - genetics
Cell Transformation, Neoplastic - genetics
Diagnostic systems
EBV
Epstein-Barr virus
exosome
Exosomes
Exosomes - genetics
Exosomes - virology
Herpes viruses
Herpesvirus 4, Human - genetics
Herpesvirus 4, Human - pathogenicity
Herpesvirus 8, Human - genetics
Herpesvirus 8, Human - pathogenicity
Humans
Kaposi's sarcoma
KSHV
Neoplasms
Neoplasms - genetics
Neoplasms - pathology
Neoplasms - virology
Sarcoma
Signal processing
Therapeutic applications
Tumorigenesis
Viruses
Title Oncogenic effects of exosomes in γ‐herpesvirus‐associated neoplasms
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjcp.28573
https://www.ncbi.nlm.nih.gov/pubmed/30941765
https://www.proquest.com/docview/2263166404
https://search.proquest.com/docview/2202679423
Volume 234
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