Histopathologic findings characteristic of CARD14‐associated papulosquamous eruption

• Published in: Journal of cutaneous pathology Vol. 47; no. 5; pp. 425 - 430
• Main Authors: Ring, Nan G., Craiglow, Brittany G., Panse, Gauri, Antaya, Richard J., Ashack, Kurt, Ashack, Richard, Faith, Esteban F., Paller, Amy S., McNiff, Jennifer M., Choate, Keith A., Ko, Christine J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.05.2020; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Biopsy; CARD Signaling Adaptor Proteins - genetics; CARD14; Case-Control Studies; Caspase; Exanthema - pathology; Guanylate Cyclase - genetics; Humans; Membrane Proteins - genetics; Middle Aged; Mutation; Papillae; papulosquamous; Pityriasis; pityriasis rubra pilaris; Pityriasis Rubra Pilaris - metabolism; Pityriasis Rubra Pilaris - pathology; Proteins - genetics; Psoriasis; Psoriasis - metabolism; Psoriasis - pathology; PSORS2; Retrospective Studies; Skin - pathology; Skin diseases; Skin Diseases, Papulosquamous - metabolism; Skin Diseases, Papulosquamous - pathology; pityriasis rubra pilaris; CARD14; psoriasis; PSORS2; papulosquamous
• ISSN: 0303-6987; 1600-0560
• DOI: 10.1111/cup.13633

Background Pathogenic mutations in caspase recruitment domain‐containing protein 14 (CARD14) lead to CARD14‐associated papulosquamous eruption, which shares clinicopathologic findings with psoriasis and pityriasis rubra pilaris. We aimed to describe distinguishing histopathologic features of CARD14‐associated papulosquamous eruption. Methods This retrospective study examined the histopathologic features of specimens from patients with confirmed CARD14‐associated papulosquamous eruption and adult patients with plaque psoriasis and pityriasis rubra pilaris. Results Lesional skin biopsies from patients with CARD14‐associated papulosquamous eruption consistently showed alternating checkerboard parakeratosis and orthokeratosis, acanthosis without acantholysis, and dilated vessels in the dermal papillae, with some cases also showing follicular plugging. Conclusion CARD14‐associated papulosquamous eruption has a range of findings, with a predominance of features typically associated with pityriasis rubra pilaris.