Dimensional changes of the maxillary sinus augmented with a collagenated synthetic bone block or synthetic bone particulates: A pre‐clinical study in rabbits

• Published in: Journal of clinical periodontology Vol. 47; no. 11; pp. 1416 - 1426
• Main Authors: Song, Young Woo, Rafikov, Komoliddin, Paeng, Kyeong‐Won, Kim, Myong Ji, Cha, Jae‐Kook, Thoma, Daniel S., Jung, Ronald E., Jung, Ui‐Won
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.11.2020
• Subjects: animal experiment; Animals; Bone grafts; Bone Substitutes - therapeutic use; Collagen; Dentistry; histology; Maxillary sinus; Maxillary Sinus - diagnostic imaging; Maxillary Sinus - surgery; micro‐computed tomography; Minerals; Osteogenesis; Rabbits; Sinus Floor Augmentation; Statistical analysis; Surgery; synthetic biphasic calcium phosphate; maxillary sinus; micro-computed tomography; histology; synthetic biphasic calcium phosphate; animal experiment
• ISSN: 0303-6979; 1600-051X
• DOI: 10.1111/jcpe.13363

Objective To compare the efficacy of a collagenated synthetic bone substitute (C‐SBS) to a particulated synthetic bone substitute (P‐SBS) in volume maintenance and new bone formations in a rabbit sinus model. Materials and Methods Either C‐SBS or P‐SBS was grafted in both sinuses of 16 rabbits. Four (N = 8) or 12 (N = 8) weeks after the surgery, total augmented volume (TAV) and area (TAA), as well as new bone volume (NBV) and area (NBA), were statistically compared by radiographic and histomorphometric analyses (p < .05). Results The differences in TAV, NBV, TAA and NBA between C‐SBS and P‐SBS groups at 4 weeks were not statistically significant. The TAV (267.13 ± 62.08 vs. 200.18 ± 40.32 mm3) and NBV (103.26 ± 10.50 vs. 71.10 ± 7.58 mm3) in group C‐SBS were significantly higher than in group P‐SBS at 12 weeks (p < .05). The TAA (19.36 ± 2.88 vs. 14.48 ± 2.08 mm2) and NBA (5.43 ± 1.20 vs. 3.76 ± 0.78 mm2) in group C‐SBS were significantly higher than in group P‐SBS at 12 weeks (p < .05). Conclusions Collagenated synthetic bone substitute grafted in rabbit sinuses demonstrated more favourable outcomes across all outcome measures compared to P‐SBS at 12 weeks.